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Information theory and signal processing methodology to identify nucleic acid-protein binding sequences in RNA-protein interactions

Harry Shaw*, Nagarajan Pattabiraman**, Deborah Preston†,  Tatiana Ammosova ††, Yuri Obukhov††, Sergei Nekhai†† and Ajit Kumar**

*Telecommunication Networks and Technologies Branch, Staff Engineer, NASA/Goddard Space Flight Center, Greenbelt, MD

**Department of Biochemistry and Molecular Medicine, The George Washington University, Washington, DC

†University of Maryland, College Park, MD

††Department of Medicine, Howard University School of Medicine, Washington DC

2019 53rd Annual Conference on Information Sciences and Systems (CISS), pp. 1-6. IEEE, 2019

Model Setup

Setting up the data for the model: A description of the three field cases used in this paper and an example of coding RNA:protein sequence of GGCUCUG:GFDLNDFLEQLR

Data setup using field cases defined RNA-protein binding
PDB structures using Chimera

Protein Data Bank (PDB) structures from the calibration dataset visualized with Chimera

Signal processing on information field spectra
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