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Information theory and signal processing methodology to identify nucleic acid-protein binding sequences in RNA-protein interactions

Harry Shaw*, Nagarajan Pattabiraman**, Deborah Preston†,  Tatiana Ammosova ††, Yuri Obukhov††, Sergei Nekhai†† and Ajit Kumar**

*Telecommunication Networks and Technologies Branch, Staff Engineer, NASA/Goddard Space Flight Center, Greenbelt, MD

**Department of Biochemistry and Molecular Medicine, The George Washington University, Washington, DC

†University of Maryland, College Park, MD

††Department of Medicine, Howard University School of Medicine, Washington DC

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2019 53rd Annual Conference on Information Sciences and Systems (CISS), pp. 1-6. IEEE, 2019

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Model Setup

Setting up the data for the model: A description of the three field cases used in this paper and an example of coding RNA:protein sequence of GGCUCUG:GFDLNDFLEQLR

Data setup using field cases defined RNA-protein binding
PDB structures using Chimera

Protein Data Bank (PDB) structures from the calibration dataset visualized with Chimera

Signal processing on information field spectra
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